Dados do Trabalho

Título

Antimicrobial resistance and profile of infections caused by Pseudomonas aeruginosa in patients admitted to an ICU in Mossoró-RN

Introdução

Pseudomonas aeruginosa is a frequent cause of hospital infections and the increase in strains resistant to multiple antibiotics prolongs the period of hospitalization, increases mortality and worries healthcare teams. Infections caused by P. aeruginosa can be difficult to treat due to limited therapeutic options, which can be associated with high mortality, reaching numbers greater than 30%.

Objetivo (s)

To determine the susceptibility profile of P. aeruginosa isolates from patients admitted to the ICU of a public hospital in Mossoró-RN and its correlation with the patient's prognosis.

Material e Métodos

This is a retrospective study carried out based on information stored in the records of UCI inpatients admitted between the period of February 2023 and January 2024. Data collection selected type of sample, underlying disease, age, outcome, antibiotics used, use of invasive devices and sensitivity profile of P. aeruginosa isolates. The project was approved by the Ethics and Research Committee (6.098.878).

Resultados e Conclusão

Of the 57 patients, 23 (40.4%) were female and 34 (59.6%) were male, with a median age of 63 years. Of the 57 P. aeruginosa isolates, most were recovered from blood cultures (10.55%), urine (15.8%) and tracheal secretions (56.1%). Regarding the use of invasive devices, 56 patients (98.2%) used an indwelling urinary catheter, 39 (68.4%) used an orotracheal tube, 43 (75.4%) had a tracheostomy. Regarding susceptibility to antimicrobials, 39 isolates were classified as extensively resistant or XDR, of which 15 patients (38.5%) died in the hospital. Still regarding the resistance profile, 38 (66.6%) of the isolates were resistant to carbapenems, of which 15 (39.5%) died, thus confirming a high mortality rate in P. aeruginosa infections resistant to carbapenems in a hospital environment.

Palavras Chave

antimicrobial resistance; Gram-negative bacteria; Hospital infection